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Ajinomoto Animal Nutrition North America, Inc. built a pilot rumen protected lysine production plant in 2011 in Eddyville, Iowa, near the heart of America’s vast Corn Belt and expanded it in 2014. With AjiPro®-L now readily available, feed producers and nutritionists can improve the nutritional balance of their feed formulas while reducing diet costs.

With amino acids being a part of the food supply chain, Ajinomoto Animal Nutrition North America, Inc. is focused on product quality and safety. It manages a comprehensive quality management system (QMS) and is certified to the ISO 9001:2008 standard. Appreciating the environmental effect of our production facility, Ajinomoto Animal Nutrition North America, Inc. operates to the ISO 14001:2004 standard.


1st project started
Decision of suspension
Breakthrough technology
April 2011
Commercial launch in U.S.
Commercial launch in Canada

The first project (1985 – 1999)
  • 300+ prototypes utilizing various technologies.
  • Project suspended due to the difficulties in achieving Ajinomoto quality and performance standards.

The second project (2006 – )
  • Re-started with a novel, breakthrough technology.
  • Focused more on product characterization in order to achieve precise formulation.
  • Pilot plant began operations in Eddyville, IA, in April 2011.
  • Efficacy and effects validated in U.S.-based universities and the Miner Institute.
  • 2ndgeneration introduction in 2014.
  • Commercial AjiPro®-L plant built in 2014.
  • AjiPro®-L launched in Canada in 2015.




Lysine is the first-limiting amino acid, or the co-limiting with methionine, in corn-based diets for high-producing dairy cows. Ajinomoto Animal Nutrition North America's AjiPro®-L contains a minimum of 40% L-Lysine on a dry matter basis (wt/wt).

Corn, which comprises a large portion of dairy cow diets in North America, is low in lysine. In order to meet the amino acid requirements of high-producing dairy cows that cannot be met only with microbial protein, high-protein ingredients such as soybean meal and animal by-product meals are commonly fed. In the past, excess protein was fed to meet the requirement of the first-limiting amino acid of dairy cows, which was also the case for swine and poultry. With the commercialization of L-Lysine, the lysine requirement of monogastric animals has been successfully met in a cost-effective manner by reducing the amount of costly, high-protein ingredients that were once fed. Because a similar advantage has been expected when formulating the dairy cow diets, if lysine could escape the rumen degradation and be efficiently delivered to the small intestine of cows, development of an effective rumen-protected lysine product has been desired.

Supplementing lysine in a form of bypass protein has sometimes failed to show the response to lysine mainly because of (1) impaired microbial protein synthesis caused by feeding an excess amount of rumen undegradable protein (RUP) and an insufficient supply of rumen degradable protein (RDP), (2) insufficient supply of metabolizable lysine from such bypass protein sources due to lower quality than expected, (3) partitioning the energy more to catabolism of excess amino acids in the liver rather than to milk and milk protein synthesis, and so on. On the other hand, a large number of studies have demonstrated that today’s high-producing dairy cows respond to higher levels of dietary lysine particularly in milk and milk protein production when lysine was duodenally or abomasally infused or when lysine was supplemented in a form of rumen protected lysine. This indicates that elevating the proportion of lysine in total metabolizable protein (MP) supplied to dairy cows would be the most effective way to improve milk and milk protein production, as it has been well documented in monogastric nutrition and commonly recognized as "an ideal protein concept."

AjiPro®-L offers dairy nutritionists flexibility and simplicity with feed formulation practices. AjiPro®-L allows nutritionists to raise the proportion of lysine in total MP (Lys/MP ratio) without adversely affecting rumen fermentation. AjiPro®-L helps reduce the use of bypass protein sources in the diet and reduces the excess supply of protein to dairy cows, which would lead to improved protein utilization efficiency and, as a consequence, decreased excretion of urinary nitrogen into the environment.

Appearance: White
L-Lysine content: 40% minimum on dry matter basis
Dry matter: No less than 95%
Specific gravity: 1.10-1.15 g/cm3

AjiPro®-L is composed of L-Lysine monohydrochloride (6.11 in AAFCO 2011), Vegetable Oil (33.2), and Lecithin (87.5).