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Ajinomoto Animal Nutrition North America, Inc. built a pilot rumen protected lysine production plant in 2011 in Eddyville, Iowa, near the heart of America’s vast Corn Belt and expanded it in 2014. With AjiPro®-L now readily available, feed producers and nutritionists can improve the nutritional balance of their feed formulas while reducing diet costs.

With amino acids being a part of the food supply chain, Ajinomoto Animal Nutrition North America, Inc. is focused on product quality and safety. It manages a comprehensive quality management system (QMS) and is certified to the ISO 9001:2008 standard. Appreciating the environmental effect of our production facility, Ajinomoto Animal Nutrition North America, Inc. operates to the ISO 14001:2004 standard.


1st project started
Decision of suspension
Breakthrough technology
April 2011
Commercial launch in U.S.
Commercial launch in Canada

The first project (1985 – 1999)
  • 300+ prototypes utilizing various technologies.
  • Project suspended due to the difficulties in achieving Ajinomoto quality and performance standards.

The second project (2006 – )
  • Re-started with a novel, breakthrough technology.
  • Focused more on product characterization in order to achieve precise formulation.
  • Pilot plant began operations in Eddyville, IA, in April 2011.
  • Efficacy and effects validated in U.S.-based universities and the Miner Institute.
  • 2ndgeneration introduction in 2014.
  • Commercial AjiPro®-L plant built in 2014.
  • AjiPro®-L launched in Canada in 2015.


Product Name: AjiPro®-L
Synonyms: Rumen Protected Lysine, RPL
Restrictions: For Animal feed only- not for human consumption

Manufacturer and Distributer: Ajinomoto Animal Nutrition North America, Inc.
1116 Hwy 137
Eddyville, Iowa 52553
Phone: 641- 969-4551 – Eddyville IA
773-380-7000 – Chicago, IL.

Hazard Identification
This product contains Soybean Oil
Eye: Avoid contact with eyes, (inflammation) otherwise non-hazardous.
Ingestion: May produce an allergic reaction
Principle Routes of Exposure: Eyes, inhalation

Composition on ingredients

Chemical Ingredient % by weight
(dry matter basis)
L-Lysine Monohydrochloride Minimum 50% 6.11 657-27-2
Vegetable Oil Approx. 49% 33.2 8016-70-4
Lecithin Approx. 1% 87.5 8030-76-0

First Aid measures
Eye Contact: Wash eyes immediately with large amounts of water or saline
Ingestion: Don’t swallow; rinse mouth with water and drink plenty of water

Fire-fighting measures
Flash Point: 540°F (Closed cup)
Auto-ignition Temperature: N/A
Flammable Limits in Air: N/A
Extinguishing Media: Dry Chemical, Foam, or Carbon Dioxide
Special Fire-Fighting Procedures: Wear Protective clothing and respiratory protection to protect from fumes of HCL and Nitrogen Oxide
Unusual Fire & Explosion Hazards: Not a fire hazard

Accidental release measures
Methods for cleaning up: Ordinary, same as food. Dispose of in accordance with all regulations

Handling and Storage
Handling: Recommended to wear gloves and dust mask if excessive handling is necessary
Storage: Keep away from sources of ignition. Store in dry conditions in sealed or closed containers
Work Place: Protective equipment: Safety glasses

Exposure controls/ Personal Protection
Hygiene measures: Handle with good industrial hygiene and safety practice. Wash hands before breaks and at the end of the day.
Ventilation: Ordinary
Protective Equipment: Safety glasses; wash hands to avoid eye contact.

Physical and Chemical Data
Bulk density: 0.63 – 0.70 grams/cm3 (39.3 – 43.6 lbs/ft3)
Appearance & Odor: Oval/circular, white, flat beads: slight characteristic odor and taste
Solubility in Water: Insoluble
Percent Volatile: 0%
Evaporation Rate: None

Stability and reactivity
Stability: Stable if stored in dry conditions at moderate temperature in sealed or closed containers
Conditions to Avoid: Hot and humid environments
Hazardous Decomposition Products: When heated to decomposition: Carbon monoxide, carbon dioxide, nitrogen oxide, and hydrogen chloride gas fumes will be emitted

Toxicological Information

Ecological Information

Disposal Considerations
Check with federal, provincial and local regulations

Transport information
Proper Shipping Name: AjiPro®-L
AAFCO#: 6.11, 33.2, 87.5

Regulatory Information

Other Information
Further Information:  The above information is believed to be accurate and represents the best information currently available to us and shall be used only as a guide. The information in this document is based on the present state of our knowledge and is applicable to the product regard to appropriate safety precautions. It does not represent any guarantee of the properties of the product. Users should make their own investigations to determine the suitability of the information for their particular purposes. Ajinomoto Animal Nutrition North America, Inc. shall not be held liable for any damage resulting in the handling or from the contact with the above product.

Prepared by: Ajinomoto Animal Nutrition North America, Inc. November 2017


For animal feed only – not for human consumption



Lysine is the first-limiting amino acid, or the co-limiting with methionine, in corn-based diets for high-producing dairy cows. Ajinomoto Animal Nutrition North America's AjiPro®-L contains a minimum of 40% L-Lysine on a dry matter basis (wt/wt).

Corn, which comprises a large portion of dairy cow diets in North America, is low in lysine. In order to meet the amino acid requirements of high-producing dairy cows that cannot be met only with microbial protein, high-protein ingredients such as soybean meal and animal by-product meals are commonly fed. In the past, excess protein was fed to meet the requirement of the first-limiting amino acid of dairy cows, which was also the case for swine and poultry. With the commercialization of L-Lysine, the lysine requirement of monogastric animals has been successfully met in a cost-effective manner by reducing the amount of costly, high-protein ingredients that were once fed. Because a similar advantage has been expected when formulating the dairy cow diets, if lysine could escape the rumen degradation and be efficiently delivered to the small intestine of cows, development of an effective rumen-protected lysine product has been desired.

Supplementing lysine in a form of bypass protein has sometimes failed to show the response to lysine mainly because of (1) impaired microbial protein synthesis caused by feeding an excess amount of rumen undegradable protein (RUP) and an insufficient supply of rumen degradable protein (RDP), (2) insufficient supply of metabolizable lysine from such bypass protein sources due to lower quality than expected, (3) partitioning the energy more to catabolism of excess amino acids in the liver rather than to milk and milk protein synthesis, and so on. On the other hand, a large number of studies have demonstrated that today’s high-producing dairy cows respond to higher levels of dietary lysine particularly in milk and milk protein production when lysine was duodenally or abomasally infused or when lysine was supplemented in a form of rumen protected lysine. This indicates that elevating the proportion of lysine in total metabolizable protein (MP) supplied to dairy cows would be the most effective way to improve milk and milk protein production, as it has been well documented in monogastric nutrition and commonly recognized as "an ideal protein concept."

AjiPro®-L offers dairy nutritionists flexibility and simplicity with feed formulation practices. AjiPro®-L allows nutritionists to raise the proportion of lysine in total MP (Lys/MP ratio) without adversely affecting rumen fermentation. AjiPro®-L helps reduce the use of bypass protein sources in the diet and reduces the excess supply of protein to dairy cows, which would lead to improved protein utilization efficiency and, as a consequence, decreased excretion of urinary nitrogen into the environment.

Appearance: White
L-Lysine content: 40% minimum on dry matter basis
Dry matter: No less than 95%
Specific gravity: 1.10-1.15 g/cm3

AjiPro®-L is composed of L-Lysine monohydrochloride (6.11 in AAFCO 2011), Vegetable Oil (33.2), and Lecithin (87.5).